Timp1

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB31024

Protein Localisation

Associated Diseases

Gene

Species	Mouse (Mus musculus)
Gene Symbol	Timp1
Gene Size (Bases)	4570
Entrez	21857

Protein

Protein Name	TIMP Metallopeptidase Inhibitor 1
Classification	ECM regulator
Mol. Weight (kD)	23
UniProtKB	P12032
Protein Domains	Netrin domain , Tissue inhibitor of metalloproteinases-like, OB-fold , Protease inhibitor I35 (TIMP) , Proteinase inhibitor I35b (TIMP), C-terminal , Tissue inhibitor of metalloproteinase, conserved site May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (3)

Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development. PubMed

Found in: Mouse (Mus musculus)

Reagents: Rb anti-human TIMP1 pAb (Biogenesis, Poole, UK)

Comment: See Fig. 3
Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis. PubMed

Found in: Mouse (Mus musculus)

Reagents: Rb anti-human TIMP-1, in house

Comment: See Fig. 10
Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice. PubMed

Found in: Mouse (Mus musculus)

Reagents: Anti-TIMP1 mAb (Abcam)

Comment: See Fig. 10

Link to hereInteractions

BM Substrates (0)

BM Ligands (5)

Gene
Mmp1b
Mmp2
Cd44
Itgb1
Mmp14

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

proteinBASE/Mouse kidney proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 2 ortholog(s) of Timp1

Drosophila — 1 ortholog(s) of Timp1

Human (Homo sapiens) — 1 ortholog(s) of Timp1

Link to hereSee also

External References

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.