TINAG

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB31035

Protein Localisation

Associated Diseases

Gene

Species	Human (Homo sapiens)
Gene Symbol	TINAG
Gene Size (Bases)	82360
Entrez	27283

Protein

Protein Name	Tubulointerstitial Nephritis Antigen
Classification	ECM glycoprotein (Matrisome Project list )
Mol. Weight (kD)	55
UniProtKB	Q9UJW2
Protein Domains	Peptidase C1A, papain C-terminal , Somatomedin B domain , Papain-like cysteine peptidase superfamily , Cysteine peptidase, asparagine active site , Peptidase C1A May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (3)

Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron PubMed

Found in: Human (Homo sapiens)

Reagents: Ms anti-TIN-ag A8 mAb, in house

Comment: See Fig. 2
A tubulointerstitial nephritis antigen gene defect causes childhood-onset chronic renal failure. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-TIN-ag mAb H79

Comment: See Fig. 1
Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms PubMed

Found in: Human (Homo sapiens)

Reagents: Ms anti-TIN-ag A8 mAb, in house

Comment: See Fig. 2

Link to hereInteractions

BM Ligands (1)

Gene
COL4A1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

proteinBASE/Human podocyte proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of TINAG

Zebrafish (Danio rerio) — 1 ortholog(s) of TINAG

Drosophila — 1 ortholog(s) of TINAG

Mouse (Mus musculus) — 1 ortholog(s) of TINAG

Link to hereSee also

External References

Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.