DDR1

Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB31112

Protein Localisation

Associated Diseases

Gene

Species	Human (Homo sapiens)
Gene Symbol	DDR1
Gene Size (Bases)	23736
Entrez	780

Protein

Protein Name	Discoidin Domain Receptor Tyrosine Kinase 1
Classification	Receptor
Mol. Weight (kD)	101
UniProtKB	Q08345
Protein Domains	Tyrosine-protein kinase, catalytic domain , Coagulation factor 5/8, C-terminal domain , Protein kinase domain , Serine-threonine/tyrosine-protein kinase, catalytic domain , Galactose-binding-like domain superfamily , Tyrosine-protein kinase, active site , Receptor Tyrosine Kinase + 5 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - ddr-1 L1 pharynx crop

Localisation Evidence (3)

DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. PubMed

Found in: Mouse (Mus musculus)

Reagents: α-DDR1 pAb - clone (C-20) (Santa Cruz Biotechnology, sc-532)

Comment: See Fig. 3
Expression of discoidin domain receptor 1 tyrosine kinase on the human bronchial epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: α-DDR1 pAb - clone (C-20) (Santa Cruz Biotechnology, sc-532)

Comment: See Fig. 3A
Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer. PubMed

Found in: Human (Homo sapiens)

Reagents: α-DDR1 pAb - clone (C-20) (Santa Cruz Biotechnology, sc-532)

Comment: See Fig. 1

Link to hereInteractions

BM Ligands (1)

Gene
COL5A1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

BM Substrates (0)

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

proteinBASE/Human podocyte proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 2 ortholog(s) of DDR1 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of DDR1

Drosophila — 2 ortholog(s) of DDR1

Mouse (Mus musculus) — 1 ortholog(s) of DDR1

Link to hereSee also

External References

Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.