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let-2 TagInt
Entry ID: BMB30535
Tag — Tagged gene or ortholog (via endogenous labelling). See the Protein Localisation tab.
Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species
Caenorhabditis elegans
Gene Symbol
let-2
Gene Size (Bases)
8744

Link to hereProtein

Protein Name
LET-2
Protein Classification
Collagen
Protein Molecular Weight (kD)
168
Protein Domains
IPR001442:Collagen IV, non-collagenous domain
This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species
Zebrafish (Danio rerio) — 5 ortholog(s) of let-2
Drosophila — 2 ortholog(s) of let-2
Human (Homo sapiens) — 5 ortholog(s) of let-2
Mouse (Mus musculus) — 5 ortholog(s) of let-2

Link to hereProtein Localisation

Localisation Images (3)

let-2 CRISPR knock-in information

LET-2::mNG in embryo

LET-2::mNG in L1 pharynx
Localisation Evidence (1)

Link to hereOther Information

Proteomics
BM Substrates (0)
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
BM Ligands (9)
Gene
emb-9
unc-52
epi-1
nid-1
mig-6
ost-1
ina-1
pat-3
mig-17
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
Associated Diseases (6)
Porencephaly 2 OMIM
Alport syndrome 2, autosomal recessive OMIM
Alport syndrome 3, autosomal dominant OMIM
Hematuria, benign familial OMIM
Alport syndrome 1, X-linked OMIM
Deafness, X-linked 6 OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References
UniProtKB/P17140 CGC Strains/NK2558
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.