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let-2

Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.
Entry ID: BMB30535
Gene
Species Caenorhabditis elegans
Gene Symbol let-2
Gene Size (Bases) 8744
Entrez
Protein
Protein Name LET-2
Classification Collagen
Mol. Weight (kD) 168
UniProtKB P17140
Protein Domains IPR001442
May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (3)

let-2 CRISPR knock-in information

LET-2::mNG in embryo

LET-2::mNG in L1 pharynx
Localisation Evidence (2)

Link to hereOther Information

Proteomics
BM Substrates (0)
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
BM Ligands (9)
Gene
emb-9
unc-52
epi-1
nid-1
mig-6
ost-1
ina-1
pat-3
mig-17
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
Interaction Network Images
Associated Diseases (6)
Porencephaly 2 OMIM
Alport syndrome 2, autosomal recessive OMIM
Alport syndrome 3, autosomal dominant OMIM
Hematuria, benign familial OMIM
Alport syndrome 1, X-linked OMIM
Deafness, X-linked 6 OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species
Zebrafish (Danio rerio) — 5 ortholog(s) of let-2
Drosophila — 2 ortholog(s) of let-2
Human (Homo sapiens) — 5 ortholog(s) of let-2
Mouse (Mus musculus) — 5 ortholog(s) of let-2

Link to hereSee also

External References
UniProtKB/P17140 CGC Strains/NK2558 Publication: A basement membrane discovery pipeline/sciadv.abn2265 CGC Strains/NK2984 CGC Strains/NK3026 CGC Strains/NK3242
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.