ADAMTS18 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 18) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR001590:Peptidase M12B, ADAM/reprolysin domain, IPR002870:Peptidase M12B, propeptide domain, Peptidase M12B, propeptide:ADAM-TS Spacer 1 domain, IPR010909:PLAC domain, IPR041645:ADAM cysteine-rich domain 2 domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of ADAMTS18

Zebrafish (Danio rerio) — 1 ortholog(s) of ADAMTS18

Mouse (Mus musculus) — 1 ortholog(s) of ADAMTS18

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (2)

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche. PubMed

Found in: Human (Homo sapiens)

Reagents: in-house ɑ-ADAMTS18 pAb (PMID: 32218432)

Comment: Figure 8
Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma. PubMed

Found in: Human (Homo sapiens)

Reagents: ɑ-ADAMTS8/18/20 (Thermo Fisher Scientific, PA5-64274)

Comment: Figure 1

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (24)

Gene
ACAN
ADAMTS1
ADAMTS2
ADAMTS3
ADAMTS4
ADAMTS5
ADAMTS6
ADAMTS7
ADAMTS8
ADAMTS9
ADAMTS10
ADAMTS13
ADAMTS14
ADAMTS15
ADAMTS16
ADAMTS17
ADAMTS19
ADAMTS20
COL15A1
COL18A1
SPON1
SPON2
THBS1
THBS2

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Microcornea, myopic chorioretinal atrophy, and telecanthus OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/170692 UniProtKB/Q8TE60

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.