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ADAMTS3 EnzInt
Entry ID: BMB30452
Enz — Basement membrane protease. See the BM Substrates tab.
Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species
Human (Homo sapiens)
Gene Symbol
ADAMTS3
Gene Size (Bases)
288253

Link to hereProtein

Protein Name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 3
Protein Classification
ECM regulator
Protein Molecular Weight (kD)
136
Protein Domains
IPR010909:PLAC domain, IPR041645:ADAM cysteine-rich domain 2 domain, IPR001590:Peptidase M12B, ADAM/reprolysin domain, IPR002870:Peptidase M12B, propeptide domain, IPR010294:ADAM-TS Spacer 1 domain
This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species
Caenorhabditis elegans — 1 ortholog(s) of ADAMTS3
Zebrafish (Danio rerio) — 1 ortholog(s) of ADAMTS3
Mouse (Mus musculus) — 1 ortholog(s) of ADAMTS3

Link to hereProtein Localisation

Localisation Images (0)
Localisation Evidence (1)

Link to hereOther Information

Proteomics
BM Substrates (9)
ADAM10, ADAMTS1, DCN, FBLN2, FN1, HSPG2, LOXL1, THBS1, VCAN
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
BM Ligands (25)
Gene
ACAN
ADAMTS1
ADAMTS2
ADAMTS4
ADAMTS5
ADAMTS6
ADAMTS7
ADAMTS8
ADAMTS9
ADAMTS10
ADAMTS13
ADAMTS14
ADAMTS15
ADAMTS16
ADAMTS17
ADAMTS18
ADAMTS19
ADAMTS20
COL2A1
COL5A1
SPON1
SPON2
THBS1
THBS2
TIMP3
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
Associated Diseases (1)
Hennekam lymphangiectasia-lymphedema syndrome 3 OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References
Entrez/9508 UniProtKB/O15072
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.