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ADAM10

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See Interactions.
Entry ID: BMB31072
Gene
Species Human (Homo sapiens)
Gene Symbol ADAM10
Gene Size (Bases) 160983
Entrez 102
Protein
Protein Name Disintegrin and metalloproteinase domain-containing protein 10
Classification ECM regulator
Mol. Weight (kD) 84
UniProtKB O14672
Protein Domains ADAM10/ADAM17 catalytic domain , Peptidase M12B, ADAM/reprolysin , Peptidase M12B, propeptide , Disintegrin domain , Metallopeptidase, catalytic domain superfamily + 3 more…
May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)
Localisation Evidence (2)

Link to hereInteractions

BM Ligands (10)
Gene
AMELX
AMTN
COL17A1
CST3
FBN1
FN1
LAMB1
LAMB2
LAMC1
ADAM17
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
BM Substrates (4)
Gene
ISLR
MEP1A
MEP1B
MMP17
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (1)
Reticulate acropigmentation of Kitamura OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereMultiomics

Proteomics

Link to hereOrthology

Orthologs by Species
Caenorhabditis elegans — 1 ortholog(s) of ADAM10
Zebrafish (Danio rerio) — 2 ortholog(s) of ADAM10
Drosophila — 2 ortholog(s) of ADAM10
Mouse (Mus musculus) — 1 ortholog(s) of ADAM10

Link to hereSee also

External References
WormBase/WBGene00006324#0-9f-10 Publication: A basement membrane discovery pipeline/sciadv.abn2265
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.