LAMB2

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB30774

Gene & Protein

Protein Localisation

Other Information

Orthology

Gene

Species	Human (Homo sapiens)
Gene Symbol	LAMB2
Gene Size (Bases)	12005
Entrez	3913

Protein

Protein Name	Laminin Subunit Beta 2
Classification	ECM glycoprotein
Mol. Weight (kD)	196
UniProtKB	P55268
Protein Domains	IPR000742, IPR002049, IPR008211, IPR013015 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture. PubMed

Found in: Human (Homo sapiens)

Reagents: LS-C88433

Comment: See Figure 1
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB2, clone 5A (Millipore, 05-206)

Comment: See Figure 2
Nanoscale protein architecture of the kidney glomerular basement membrane. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB2 rb pAb, LF-domain, in-house

Comment: See Figure 2/S2
Laminin-511 and -521 enable efficient in vitro expansion of human corneal endothelial cells PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB2, in-house

Comment: See Figure 1

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (38)

Gene
AGRN
AMELX
AMTN
CST3
FBN1
FN1
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB3
LAMC1
LAMC2
LAMC3
NID1
NID2
NTN4
SPARCL1
TIMP1
TNC
USH2A
VCAN
VWA1
ADAM10
DAG1
EVA1A
GPC3
ITGA1
ITGA2
ITGA3
ITGA6
ITGA7
ITGB1
RPSA
ITGB4

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (2)

Nephrotic syndrome, type 5, with or without ocular abnormalitie HPO

Pierson syndrome HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of LAMB2 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of LAMB2

Drosophila — 1 ortholog(s) of LAMB2

Mouse (Mus musculus) — 1 ortholog(s) of LAMB2

Link to hereSee also

External References

Entrez/3913 UniProtKB/P55268 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.