HSPG2

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB30738

Gene & Protein

Protein Localisation

Other Information

Orthology

Gene

Species	Human (Homo sapiens)
Gene Symbol	HSPG2
Gene Size (Bases)	115067
Entrez	3339

Protein

Protein Name	Heparan Sulfate Proteoglycan 2
Classification	Proteoglycan
Mol. Weight (kD)	469
UniProtKB	P98160
Protein Domains	EGF-like domain , Immunoglobulin domain subtype , Immunoglobulin-like domain , Immunoglobulin V-set domain , Immunoglobulin subtype 2 , Immunoglobulin I-set , Immunoglobulin domain subtype , Immunoglobulin-like domain , Immunoglobulin V-set domain , SEA domain , Laminin G domain , EGF-like calcium-binding domain , Laminin-type EGF domain , Laminin G domain , EGF-like calcium-binding domain , Immunoglobulin subtype 2 , Laminin IV , Immunoglobulin I-set , Immunoglobulin-like fold , LDL receptor-like superfamily + 21 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (1)

unc-52 L4 pharynx

Localisation Evidence (6)

Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin. PubMed

Found in: Human (Homo sapiens)

Reagents: perlecan, 3G166 against domain III (US Biologicals, Swampscott, USA)

Comment: See Figure 1
Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, mAb 7B5

Comment: See Figures 3-5
The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, A7L6/C11L1

Comment: See Figure 5
Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera PubMed

Found in: Human (Homo sapiens)

Reagents: mAb 5C9 within domain IV (Developmental Studies Hybridoma Bank)

Comment: See Figure 1
Compositional differences between infant and adult human corneal basement membranes. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, A7L6/C11L1

Comment: See Figure 2
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, domain V and III

Comment: See Figure 1

Link to hereOther Information

Proteomics

Matrisome Project/Proteoglycans

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (54)

Gene
ACAN
ACHE
AGRN
BCAN
BGN
COL4A1
COL4A2
COL18A1
COLQ
CST3
DCN
ECM1
FBLN1
FBLN2
FBN1
FGF9
FMOD
FN1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMC1
LAMC2
LAMC3
LUM
NID1
NID2
SPARC
TGFB1
TGFBI
THBS1
TINAGL1
TLL1
VCAN
VTN
VWA1
CD44
CSPG4
DAG1
GPC1
GPC2
GPC3
GPC4
GPC5
GPC6
ITGA2
ITGB1
SDC4
SDC1
MMP14

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (2)

Dyssegmental dysplasia, Silverman-Handmaker type HPO

Schwartz-Jampel syndrome, type 1 HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of HSPG2 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of HSPG2

Drosophila — 1 ortholog(s) of HSPG2

Mouse (Mus musculus) — 1 ortholog(s) of HSPG2

Link to hereSee also

External References

Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.