HSPG2 (Heparan Sulfate Proteoglycan 2) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000742:EGF-like domain, IPR003599:Immunoglobulin subtype domain, IPR007110:Immunoglobulin-like domain, IPR013106:Immunoglobulin V-set domain, IPR002049:Laminin EGF domain domain, IPR001791:Laminin G domain, IPR001881:EGF-like calcium-binding domain, IPR003598:Immunoglobulin subtype 2 domain, IPR000034:Laminin IV domain, IPR013098:Immunoglobulin I-set domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of HSPG2 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of HSPG2

Drosophila — 1 ortholog(s) of HSPG2

Mouse (Mus musculus) — 1 ortholog(s) of HSPG2

Link to hereProtein Localisation

Localisation Images (1)

unc-52 L4 pharynx

Localisation Evidence (6)

Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skin. PubMed

Found in: Human (Homo sapiens)

Reagents: perlecan, 3G166 against domain III (US Biologicals, Swampscott, USA)

Comment: See Figure 1
Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, mAb 7B5

Comment: See Figures 3-5
The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, A7L6/C11L1

Comment: See Figure 5
Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera PubMed

Found in: Human (Homo sapiens)

Reagents: mAb 5C9 within domain IV (Developmental Studies Hybridoma Bank)

Comment: See Figure 1
Compositional differences between infant and adult human corneal basement membranes. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, A7L6/C11L1

Comment: See Figure 2
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-perlecan, domain V and III

Comment: See Figure 1

Link to hereOther Information

Proteomics

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (41)

Gene
AGRN
COL4A1
COL4A2
COL18A1
COLQ
CST3
FBLN1
FBLN2
FBN1
FN1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMC1
LAMC2
LAMC3
NID1
NID2
SPARC
TGFBI
TLL1
VCAN
VWA1
CD44
CSPG4
DAG1
GPC1
GPC2
GPC3
GPC4
GPC5
GPC6
ITGA2
ITGB1
SDC4
SDC1
MMP14

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (2)

Dyssegmental dysplasia, Silverman-Handmaker type HPO

Schwartz-Jampel syndrome, type 1 HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/3339 UniProtKB/P98160

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.