ACAN (Aggrecan) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000436:Sushi/SCR/CCP domain, IPR000538:Link domain, IPR000742:EGF-like domain, IPR003599:Immunoglobulin subtype domain, IPR007110:Immunoglobulin-like domain, IPR013106:Immunoglobulin V-set domain, IPR033987:Aggrecan/versican, C-type lectin-like domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Zebrafish (Danio rerio) — 2 ortholog(s) of ACAN

Mouse (Mus musculus) — 1 ortholog(s) of ACAN

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (2)

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera PubMed

Found in: Human (Homo sapiens)

Reagents: a-ACAN mAb (R&D Systems, 179509)
Proteoglycan expression patterns in human hair follicle PubMed

Found in: Human (Homo sapiens)

Reagents: a-ACAN mAb (Novus Biologicals, HAG7D4)

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (16)

Gene
ADAMTS1
ADAMTS3
ADAMTS4
ADAMTS5
ADAMTS8
ADAMTS9
ADAMTS16
ADAMTS18
HAPLN1
MMP1
MMP2
MMP7
OGN
TNC
CD44
MMP14

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (3)

Spondyloepiphyseal dysplasia, Kimberley type OMIM

Spondyloepimetaphyseal dysplasia, aggrecan type OMIM

Short Stature And Advanced Bone Age, With Or Without Early-onset Osteoarthritis And/or Osteochondrit OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/176 UniProtKB/P16112 Matrisome Project/246

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.