LUM

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB30804

Protein Localisation

Associated Diseases

Gene

Species	Human (Homo sapiens)
Gene Symbol	LUM
Gene Size (Bases)	8866
Entrez	4060

Protein

Protein Name	Lumican
Classification	Proteoglycan
Mol. Weight (kD)	38
UniProtKB	P51884
Protein Domains	Leucine-rich repeat N-terminal domain , Leucine-rich repeat , Leucine-rich repeat, typical subtype , Leucine-rich repeat domain superfamily , Small Leucine-Rich Proteoglycans May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (2)

Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera PubMed

Found in: Human (Homo sapiens)

Reagents: anti-lumican AP pAb (R&D systems)

Comment: See Figure 3
Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican PubMed

Found in: Human (Homo sapiens)

Reagents: anti-C terminal of hLUM rb pAb, in-house

Comment: See Figure 7

Link to hereInteractions

BM Ligands (27)

Gene
ACAN
BGN
COL2A1
COL5A1
COL6A2
COL6A3
COL12A1
COL14A1
DCN
FBN1
FBN2
FMOD
FN1
HSPG2
MMP2
OGN
POSTN
SPARC
TGFB2
TGFB1
THBS2
VCAN
ITGA2
ITGB1
MMP14
COL5A2
COL5A3

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

Matrisome Project/Proteoglycans

proteinBASE/Human podocyte proteomics

Link to hereOrthology

Orthologs by Species

Zebrafish (Danio rerio) — 1 ortholog(s) of LUM

Mouse (Mus musculus) — 1 ortholog(s) of LUM

Link to hereSee also

External References

Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.