FBN2

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB30688

Protein Localisation

Other Information

Gene

Species	Human (Homo sapiens)
Gene Symbol	FBN2
Gene Size (Bases)	401277
Entrez	2201

Protein

Protein Name	Fibrillin 2
Classification	ECM glycoprotein
Mol. Weight (kD)	315
UniProtKB	P35556
Protein Domains	IPR000742, IPR026823, IPR017878, IPR040872, IPR001881 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

Human eye development is characterized by coordinated expression of fibrillin isoforms. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-fibrillin-2 rb pAb

Comment: See Figure 2
Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences PubMed

Found in: Human (Homo sapiens)

Reagents: anti-FBN2 rb mAb clones 48 and 143

Comment: See Figure 6
Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-FBN2 pAb - HPA012853

Comment: See Figure 2
Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury PubMed

Found in: Human (Homo sapiens)

Reagents: anti-FBN2 sera

Comment: See Figure 3

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (7)

Gene
FBN1
FBN3
ITGA5
ITGAV
ITGB1
ITGB3
ITGB6

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (2)

Contractural arachnodactyly, congenital HPO

Macular degeneration, early-onset HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of FBN2

Zebrafish (Danio rerio) — 2 ortholog(s) of FBN2

Drosophila — 1 ortholog(s) of FBN2

Mouse (Mus musculus) — 1 ortholog(s) of FBN2

Link to hereSee also

External References

Entrez/2201 UniProtKB/P35556 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.