ITGB1

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB31215

Gene & Protein

Protein Localisation

Other Information

Orthology

Gene

Species	Human (Homo sapiens)
Gene Symbol	ITGB1
Gene Size (Bases)	105475
Entrez	3688

Protein

Protein Name	Integrin subunit beta 1
Classification	Receptor
Mol. Weight (kD)	88
UniProtKB	P05556
Protein Domains	IPR016201, IPR012896, IPR013111, IPR014836, IPR033760, IPR040622, IPR002369 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - pat-3 L1 pharynx crop

Localisation Evidence (4)

Appearance and distribution of laminin A chain isoforms and integrin alpha 2, alpha 3, alpha 6, beta 1, and beta 4 subunits in the developing human small intestinal mucosa PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-Integrin beta1 (CD29) [mAb13] (Sigma-Aldrich #MABT821)

Comment: See Fig. 2
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes PubMed

Found in: Human (Homo sapiens)

Reagents: mouse mAb anti-Integrin α3β1 (Millipore, #MAB1992)

Comment: See Fig. 3
Basement membrane formation and re-distribution of the beta 1 integrins in a human intestinal co-culture system PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-Integrin beta1 (CD29) [mAb13] (Sigma-Aldrich #MABT821)

Comment: See Fig. 5
Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgβ1 mAb (Chemicon, MAB1959Z)

Comment: See Fig. 2

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (42)

Gene
AGRN
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL5A1
COL6A1
COL6A2
COL6A3
COL7A1
COL9A1
COL9A2
COL9A3
COL18A1
FBN1
FBN2
FBN3
FN1
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
LUM
NID1
NPNT
TGFB1
TGFBI
THBS1
THBS2
TNC
VTN

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of ITGB1 Tag

Zebrafish (Danio rerio) — 2 ortholog(s) of ITGB1

Drosophila — 1 ortholog(s) of ITGB1

Mouse (Mus musculus) — 1 ortholog(s) of ITGB1

Link to hereSee also

External References

Entrez/3688 UniProtKB/P05556 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.