TNC

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB31048

Protein Localisation

Other Information

Gene

Species	Human (Homo sapiens)
Gene Symbol	TNC
Gene Size (Bases)	98683
Entrez	3371

Protein

Protein Name	Tenascin C
Classification	ECM glycoprotein
Mol. Weight (kD)	241
UniProtKB	P24821
Protein Domains	IPR000742, IPR003961, IPR041161, IPR002181, IPR013111 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (6)

Value of tenascin-C content and association with clinicopathological parameters in uterine cervical lesions. PubMed

Found in: Human (Homo sapiens)

Reagents: Ms anti-human Tn-C mAb (Dako)

Comment: See Fig. 1
Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-human TNC TN2 (Dako and Novocasta Laboratories), Anti-human TNC 49 (Dako and Novocasta Laboratories)

Comment: See Fig. 3
Roles of the matricellular protein Tenascin-C in T-lymphocyte trafficking and etiopathogenesis of Oral Lichen Planus. PubMed

Found in: Human (Homo sapiens)

Reagents: Rb anti-TNC mAb (Abcam, ab108930)

Comment: See Fig. 1
Progression of human aortic valve stenosis is associated with tenascin-C expression PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-human TNC mAb 143DB7

Comment: See Fig. 1
Compositional differences between infant and adult human corneal basement membranes. PubMed

Found in: Human (Homo sapiens)

Reagents: Ms anti-tenascin C mAb

Comment: See Fig. 7
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-TNC (Dako)

Comment: See Fig. 2

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (26)

Gene
ACAN
AMELX
AMTN
BCAN
CST3
FBN1
FN1
LAMB1
LAMB2
LAMC1
SPARCL1
TIMP1
VCAN
VWA1
ITGA2
ITGA9
ITGAX
ITGA5
ITGA8
ITGA7
ITGAV
ITGB1
SDC4
ITGB3
ITGB6
SDC1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (1)

Deafness, autosomal dominant 56 OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Zebrafish (Danio rerio) — 1 ortholog(s) of TNC

Mouse (Mus musculus) — 1 ortholog(s) of TNC

Link to hereSee also

External References

Entrez/3371 UniProtKB/P24821 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.