ITGA6

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB31178

Gene & Protein

Protein Localisation

Other Information

Orthology

Gene

Species	Human (Homo sapiens)
Gene Symbol	ITGA6
Gene Size (Bases)	79124
Entrez	3655

Protein

Protein Name	Integrin subunit alpha 6
Classification	Receptor
Mol. Weight (kD)	127
UniProtKB	P23229
Protein Domains	IPR013649 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - ina-1 L1 pharynx crop

Localisation Evidence (4)

Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction PubMed

Found in: Human (Homo sapiens)

Reagents: Rb mAb anti-ITGA6 [EPR18124] (Abcam, ab181551)

Comment: See Fig. 4
Expression of integrins and basement membrane components by wound keratinocytes PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα6 mAb clone GoH3 (Abcam, ab105669)

Comment: See Fig. 7
Distribution of integrins during human fetal lung development PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα6 mAb clone GoH3 (Abcam, ab105669)

Comment: See Fig. 1
Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects PubMed

Found in: Human (Homo sapiens)

Reagents: mouse α-Itgα6 mAb (Chemicon)

Comment: See Fig. 2

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (19)

Gene
AGRN
COL4A1
COL4A2
COL6A1
COL17A1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
THBS1
THBS2
VTN

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (1)

Epidermolysis Bullosa Junctionalis With Pyloric Atresia OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of ITGA6 Tag

Zebrafish (Danio rerio) — 2 ortholog(s) of ITGA6

Drosophila — 1 ortholog(s) of ITGA6

Mouse (Mus musculus) — 1 ortholog(s) of ITGA6

Link to hereSee also

External References

Entrez/3655 UniProtKB/P23229 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.