LAMA1

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB30749

Gene & Protein

Protein Localisation

Other Information

Orthology

Gene

Species	Human (Homo sapiens)
Gene Symbol	LAMA1
Gene Size (Bases)	176056
Entrez	284217

Protein

Protein Name	Laminin Subunit Alpha 1
Classification	ECM glycoprotein
Mol. Weight (kD)	337
UniProtKB	P25391
Protein Domains	IPR000742, IPR001791, IPR000034, IPR002049, IPR008211, IPR009254, IPR009254 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (3)

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture. PubMed

Found in: Human (Homo sapiens)

Reagents: LS-C25112

Comment: See Figure 1
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation PubMed

Found in: Human (Homo sapiens)

Reagents: LS-C119557

Comment: See Figure S2
Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin PubMed

Found in: Human (Homo sapiens)

Reagents: rb antiserum raised against lamimin a1 HK-175

Comment: See Figure 1

Link to hereOther Information

Proteomics

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (39)

Gene
AGRN
COL17A1
COL18A1
FBLN2
HSPG2
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
NID1
NID2
NTN4
DAG1
GPC1
ITGA1
ITGA2
ITGA3
ITGA4
ITGA6
ITGA9
ITGA10
ITGA5
ITGA8
ITGA7
ITGAV
ITGB1
RPSA
SDC4
ITGB3
ITGB4
ITGB5
ITGB6
ITGB7

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (1)

Poretti-boltshauser Syndrome HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 2 ortholog(s) of LAMA1 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of LAMA1

Drosophila — 1 ortholog(s) of LAMA1

Mouse (Mus musculus) — 1 ortholog(s) of LAMA1

Link to hereSee also

External References

Entrez/284217 UniProtKB/P25391 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.