DAG1

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB31102

Protein Localisation

Associated Diseases

Gene

Species	Human (Homo sapiens)
Gene Symbol	DAG1
Gene Size (Bases)	66916
Entrez	1605

Protein

Protein Name	Dystroglycan 1
Classification	Receptor
Mol. Weight (kD)	97
UniProtKB	Q14118
Protein Domains	Dystroglycan-type cadherin-like , Dystroglycan, C-terminal , DG-type SEA domain , Alpha-dystroglycan N-terminal domain 2 , Immunoglobulin-like fold , Alpha-dystroglycan domain 2 , Cadherin-like superfamily + 2 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - dgn-1 L1 pharynx crop

Localisation Evidence (2)

Podocin and beta dystroglycan expression to study podocyte-podocyte and basement membrane matrix connections in adult protienuric states. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-β-dystroglycan (Vector laboratory, VP-B205)

Comment: See Fig. 1
Dystroglycan expression in human placenta: basement membrane localization and subunit distribution change between the first and third trimester. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-α-dystroglycan mAb - clone IIH6 (Millipore, 05-593)

Comment: See Fig. 1

Link to hereInteractions

BM Ligands (19)

Gene
AGRN
BGN
EGFLAM
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
NID1
SLIT2
ITGA7
MUSK

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

BM Substrates (0)

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (2)

Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 9 OMIM

Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9 OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereMultiomics

Proteomics

Proteomics evidence available

proteinBASE/Human podocyte proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 2 ortholog(s) of DAG1 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of DAG1

Drosophila — 1 ortholog(s) of DAG1

Mouse (Mus musculus) — 1 ortholog(s) of DAG1

Link to hereSee also

External References

Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.