LAMA2

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB30755

Gene & Protein

Protein Localisation

Other Information

Orthology

Gene

Species	Human (Homo sapiens)
Gene Symbol	LAMA2
Gene Size (Bases)	633432
Entrez	3908

Protein

Protein Name	Laminin Subunit Alpha 2
Classification	ECM glycoprotein
Mol. Weight (kD)	344
UniProtKB	P24043
Protein Domains	IPR000742, IPR001791, IPR000034, IPR002049, IPR008211, IPR009254, IPR010307 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (3)

Compositional differences between infant and adult human corneal basement membranes. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LNa2 1F9

Comment: See Figure 4
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LNa2, in-house

Comment: See Figure 2
Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. PubMed

Found in: Human (Homo sapiens)

Reagents: affinity purified rb pAb - mouse LG1-3 domain and human clone 4H8-2

Comment: See Figure 2

Link to hereOther Information

Proteomics

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (34)

Gene
AGRN
HSPG2
LAMA1
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
NID1
NID2
NTN4
DAG1
ITGA1
ITGA2
ITGA3
ITGA4
ITGA6
ITGA9
ITGA10
ITGA5
ITGA8
ITGA7
ITGAV
ITGB1
RPSA
ITGB3
ITGB4
ITGB5
ITGB6
ITGB7

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (2)

Muscular dystrophy, limb-girdle, autosomal recessive 23 HPO

Muscular Dystrophy, Congenital Merosin-deficient, 1a HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 2 ortholog(s) of LAMA2 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of LAMA2

Drosophila — 1 ortholog(s) of LAMA2

Mouse (Mus musculus) — 1 ortholog(s) of LAMA2

Link to hereSee also

External References

Entrez/3908 UniProtKB/P24043 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.