ITGB4

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB31259

Protein Localisation

Other Information

Gene

Species	Human (Homo sapiens)
Gene Symbol	ITGB4
Gene Size (Bases)	36492
Entrez	3691

Protein

Protein Name	Integrin subunit beta 4
Classification	Receptor
Mol. Weight (kD)	202
UniProtKB	P16144
Protein Domains	IPR003961, IPR016201, IPR003644, IPR012896, IPR013111, IPR033760, IPR040622, IPR002369 May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (5)

Appearance and distribution of laminin A chain isoforms and integrin alpha 2, alpha 3, alpha 6, beta 1, and beta 4 subunits in the developing human small intestinal mucosa PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-ITGB4 clone 3E1 (Chemicon, MAB196)

Comment: See Fig. 2
Distribution of integrins during human fetal lung development PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-ITGB4 clone 3E1 (Chemicon, MAB196)

Comment: See Fig. 3
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction PubMed

Found in: Human (Homo sapiens)

Reagents: Rb mAb anti-ITGB4 clone EPR17517 (Abcam, ab182120)

Comment: See Fig. 4
Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-ITGB4 clone 3E1 (Chemicon, MAB196)

Comment: See Fig. 2
Expression of integrins and basement membrane components by wound keratinocytes PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgβ4 mAb - clone 345-11A, in house

Comment: See Fig. 7

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (19)

Gene
COL4A2
COL4A3
COL4A4
COL4A5
COL6A1
COL6A3
COL17A1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMB4
LAMC1
LAMC2
THBS1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (3)

Epidermolysis bullosa, junctional, non-Herlitz type HPO

Epidermolysis Bullosa Junctionalis With Pyloric Atresia OMIM

Epidermolysis Bullosa Simplex, Weber-cockayne Type OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of ITGB4

Zebrafish (Danio rerio) — 1 ortholog(s) of ITGB4

Drosophila — 1 ortholog(s) of ITGB4

Mouse (Mus musculus) — 1 ortholog(s) of ITGB4

Link to hereSee also

External References

Entrez/3691 UniProtKB/P16144 Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.