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ADAM17 EnzInt
Entry ID: BMB31078
Enz — Basement membrane protease. See the BM Substrates tab.
Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species
Human (Homo sapiens)
Gene Symbol
ADAM17
Gene Size (Bases)
68247

Link to hereProtein

Protein Name
Disintegrin and metalloproteinase domain-containing protein 17
Protein Classification
ECM regulator
Protein Molecular Weight (kD)
93
Protein Domains
IPR034025:ADAM10/ADAM17 catalytic domain, IPR032029:ADAM17, membrane-proximal domain, IPR001590:Peptidase M12B, ADAM/reprolysin domain, IPR002870:Peptidase M12B, propeptide domain, IPR001762:Disintegrin domain
This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species
Caenorhabditis elegans — 1 ortholog(s) of ADAM17
Zebrafish (Danio rerio) — 2 ortholog(s) of ADAM17
Drosophila — 1 ortholog(s) of ADAM17
Mouse (Mus musculus) — 1 ortholog(s) of ADAM17

Link to hereProtein Localisation

Localisation Images (0)
Localisation Evidence (0)

Link to hereOther Information

Proteomics
BM Substrates (1)
DDR1
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
BM Ligands (1)
Gene
COL17A1
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
Associated Diseases (1)
Inflammatory skin and bowel disease, neonatal, 1 OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References
Entrez/6868 UniProtKB/P78536
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.