SPARC

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See BM Ligands.

Entry ID: BMB30964

Gene & Protein

Protein Localisation

Other Information

Orthology

Gene

Species	Human (Homo sapiens)
Gene Symbol	SPARC
Gene Size (Bases)	25880
Entrez	6678

Protein

Protein Name	Secreted Protein Acidic And Cysteine Rich
Classification	ECM glycoprotein
Mol. Weight (kD)	35
UniProtKB	P09486
Protein Domains	SPARC/Testican, calcium-binding domain , Follistatin/Osteonectin EGF domain , Kazal domain , Follistatin-like, N-terminal , Kazal domain superfamily , EF-hand domain pair , EF-Hand 1, calcium-binding site , Osteonectin-like, conserved site , SPARC, follistatin-like domain + 4 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (1)

C.elegans ost-1 2-fold embryo pharynx

Localisation Evidence (4)

Patterns of SPARC expression and basement membrane intactness at the tumour-brain border of invasive meningiomas. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-SPARC mAb (Harmatological Technologies)

Comment: See Fig. 1
Involvement of SPARC and MMP-3 in the pathogenesis of human pterygium. PubMed

Found in: Human (Homo sapiens)

Reagents: Goat anti-SPARC pAb (R&D systems, AF941)

Comment: See Fig. 2
Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. PubMed

Found in: Human (Homo sapiens)

Reagents: Rb anti-BM40/SPARC pAb, in house

Comment: See Fig. 3
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: Rb anti-BM40/SPARC pAb, in house

Comment: See Fig. 2

Link to hereOther Information

Proteomics

Matrisome Project/ECM Glycoproteins

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (27)

Gene
BGN
COL2A1
COL4A1
COL4A2
COL5A1
COL6A1
COL18A1
DCN
FN1
HSPG2
ISLR
LUM
MMP2
NID1
PAPLN
POSTN
PTN
RECK
SMOC1
SPOCK1
SPOCK3
TGFB2
TGFB1
THBS1
THBS2
TIMP1
VTN

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (1)

Osteogenesis imperfecta, type Xvii OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of SPARC Tag

Zebrafish (Danio rerio) — 3 ortholog(s) of SPARC

Drosophila — 1 ortholog(s) of SPARC

Mouse (Mus musculus) — 1 ortholog(s) of SPARC

Link to hereSee also

External References

Publication: A basement membrane discovery pipeline/sciadv.abn2265

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.