Fras1

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB30709

Protein Localisation

Associated Diseases

Gene

Species	Mouse (Mus musculus)
Gene Symbol	Fras1
Gene Size (Bases)	410774
Entrez	231470

Protein

Protein Name	Fraser Extracellular Matrix Complex Subunit 1
Classification	ECM glycoprotein
Mol. Weight (kD)	442
UniProtKB	Q80T14
Protein Domains	EGF-like domain , Na-Ca exchanger/integrin-beta4 , VWFC domain , CSPG repeat , Growth factor receptor cysteine-rich domain superfamily , CalX-like domain superfamily , Furin-like repeat , FRAS1-related extracellular matrix + 3 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (8)

Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development. PubMed

Found in: Mouse (Mus musculus)

Reagents: Rabbit anti-Fras

Comment: See Figures 1-5
AMACO is a component of the basement membrane-associated Fraser complex. PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-FRAS1 CSPG

Comment: See Figure 3
Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa. PubMed

Found in: Mouse (Mus musculus)

Reagents: Rabbit anti-Fras

Comment: See Figure 1
Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice PubMed

Found in: Mouse (Mus musculus)

Reagents: Rabbit anti-Fras

Comment: See Figure 5
Overlapping and divergent localization of Frem1 and Fras1 and its functional implications during mouse embryonic development PubMed

Found in: Mouse (Mus musculus)

Reagents: Rabbit anti-Fras

Comment: See Figure 1
Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1 PubMed

Found in: Mouse (Mus musculus)

Reagents: Rabbit anti-Fras1

Comment: See Figure 3
Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects PubMed

Found in: Mouse (Mus musculus)

Reagents: Rabbit anti-Fras1

Comment: See Figure 3
Fras1 immunohistochemistry Matrixome project

Found in: Mouse (Mus musculus)

Reagents: Rabbit pAb anti-Fras1 ectodomain (MATRIXOME PJ)

Comment: The Matrixome Project, Fras1 E16.5 Whole body

Link to hereInteractions

BM Ligands (2)

Gene
Frem1
Frem2

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

proteinBASE/Mouse kidney proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of Fras1

Zebrafish (Danio rerio) — 1 ortholog(s) of Fras1

Human (Homo sapiens) — 1 ortholog(s) of Fras1

Link to hereSee also

External References

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.