Frem2

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB30717

Protein Localisation

Associated Diseases

Gene

Species	Mouse (Mus musculus)
Gene Symbol	Frem2
Gene Size (Bases)	143418
Entrez	242022

Protein

Protein Name	FRAS1 Related Extracellular Matrix 2
Classification	ECM-affiliated protein
Mol. Weight (kD)	351
UniProtKB	Q6NVD0
Protein Domains	Na-Ca exchanger/integrin-beta4 , CSPG repeat , CalX-like domain superfamily , FRAS1-related extracellular matrix , FRAS1-related extracellular matrix protein, N-terminal domain May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa. PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-FREM2 rb pAb

Comment: See Figure 1
Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development. PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-FREM2 rb pAb

Comment: See Figures 1-5
Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1 PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-FREM2 rb pAb (2)

Comment: See Figure 3
Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-FREM2 rb pAb (2)

Comment: See Figure 3

Link to hereInteractions

BM Ligands (2)

Gene
Fras1
Frem1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

BM Substrates (0)

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

proteinBASE/Mouse kidney proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of Frem2

Zebrafish (Danio rerio) — 2 ortholog(s) of Frem2

Human (Homo sapiens) — 1 ortholog(s) of Frem2

Link to hereSee also

External References

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