Frem1

Ab — Antibody evidence. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB30713

Protein Localisation

Associated Diseases

Gene

Species	Mouse (Mus musculus)
Gene Symbol	Frem1
Gene Size (Bases)	154420
Entrez	329872

Protein

Protein Name	FRAS1-related extracellular matrix protein 1
Classification	ECM-affiliated protein
Mol. Weight (kD)	245
UniProtKB	Q684R7
Protein Domains	Na-Ca exchanger/integrin-beta4 , C-type lectin-like , CSPG repeat , C-type lectin-like/link domain superfamily , C-type lectin fold , CalX-like domain superfamily , FRAS1-related extracellular matrix + 3 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (6)

Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa. PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-FREM1 rb pAb

Comment: See Figure 1
Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development. PubMed

Found in: Mouse (Mus musculus)

Reagents: affinity purified anti-FREM1

Comment: See Figures 1-5
Overlapping and divergent localization of Frem1 and Fras1 and its functional implications during mouse embryonic development PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-FREM1 rb pAb

Comment: See Figures 1-3
Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1 PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-QBRICK/Frem1

Comment: See Figure 3
Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-QBRICK/Frem1

Comment: See Figure 3
QBRICK/Frem1 Immunohistochemistry Matrixome project

Found in: Mouse (Mus musculus)

Reagents: Rabbit pAb anti-QBRICK/Frem1 NV domain

Comment: The Matrixome Project, QBRICK/Frem1 E16.5 Whole body

Link to hereInteractions

BM Ligands (2)

Gene
Fras1
Frem2

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

BM Substrates (0)

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

proteinBASE/Mouse kidney proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of Frem1

Zebrafish (Danio rerio) — 2 ortholog(s) of Frem1

Human (Homo sapiens) — 1 ortholog(s) of Frem1

Link to hereSee also

External References

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.