Hspg2

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation. Int — Basement membrane interaction. See Interactions.

Entry ID: BMB30739

Gene & Protein

Protein Localisation

Gene

Species	Mouse (Mus musculus)
Gene Symbol	Hspg2
Gene Size (Bases)	101862
Entrez	15530

Protein

Protein Name	Heparan Sulfate Proteoglycan 2
Classification	Proteoglycan
Mol. Weight (kD)	398
UniProtKB	Q05793
Protein Domains	EGF-like domain , Immunoglobulin domain subtype , Immunoglobulin-like domain , Immunoglobulin V-set domain , Immunoglobulin subtype 2 , Immunoglobulin I-set , SEA domain , Laminin G domain , EGF-like calcium-binding domain , Laminin-type EGF domain , Laminin IV , Immunoglobulin-like fold , LDL receptor-like superfamily + 14 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (5)

Perlecan and syndecan-4 in uterine tissues during the early pregnancy in mice PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-perlecan rt mAb against domain V (Chemicon)

Comment: See Figures 1-2
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-perlecan (Chemicon, mAb1948)

Comment: See Figure 1
Mammalian tissue distribution of a large heparan sulfate proteoglycan detected by monoclonal antibodies PubMed

Found in: Mouse (Mus musculus)

Reagents: rat mAbs against HSPG

Comment: See Figure 5
The γ3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-perlecan rt mAb against domain V (Chemicon)

Comment: See Figure 2
Perlecan immunohistochemistry Matrixome project

Found in: Mouse (Mus musculus)

Reagents: anti-perlecan (Chemicon, mAb1948)

Comment: The Matrixome Project, perlecan E16.5 Whole body

Link to hereInteractions

BM Ligands (16)

Gene
Ache
Agrn
Bgn
Col18a1
Dcn
Ecm1
Fbln1
Fbln2
Fgf9
Fn1
Lama1
Nid1
Nid2
Vwa1
Dag1
Sdc1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Link to hereAssociated Diseases

Associated Diseases (0)

Link to hereMultiomics

Proteomics

proteinBASE/Mouse kidney proteomics

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of Hspg2 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of Hspg2

Drosophila — 1 ortholog(s) of Hspg2

Human (Homo sapiens) — 1 ortholog(s) of Hspg2 Tag

Link to hereSee also

External References

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.