Dag1

Ab — Antibody evidence. See Protein Localisation. Tag — Tagged gene or ortholog. See Protein Localisation.

Entry ID: BMB31103

Protein Localisation

Other Information

Gene

Species	Mouse (Mus musculus)
Gene Symbol	Dag1
Gene Size (Bases)	59117
Entrez	13138

Protein

Protein Name	Dystroglycan 1
Classification	Receptor
Mol. Weight (kD)	97
UniProtKB	Q62165
Protein Domains	Dystroglycan-type cadherin-like , Dystroglycan, C-terminal , DG-type SEA domain , Alpha-dystroglycan N-terminal domain 2 , Immunoglobulin-like fold , Alpha-dystroglycan domain 2 , Cadherin-like superfamily + 2 more… May not be up to date — see InterPro .

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

β2 and γ3 laminins are critical cortical basement membrane components: ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia PubMed

Found in: Mouse (Mus musculus)

Reagents: α-43DAG mAb - clone 8D5 (Novocastra, NCL-b-DG)

Comment: See Fig. 2
Slit/Robo signals prevent spinal motor neuron emigration by organizing the spinal cord basement membrane. PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-α-dystroglycan mAb - clone IIH6 C4 (Dev. Studies Hybridoma Bank)

Comment: See Fig. 4
Dystroglycan binding to laminin alpha1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro. PubMed

Found in: Mouse (Mus musculus)

Reagents: α-43DAG mAb - clone 8D5 (Novocastra, NCL-b-DG)

Comment: See Fig. 3
Dystroglycan does not contribute significantly to kidney development or function, in health or after injury. PubMed

Found in: Mouse (Mus musculus)

Reagents: anti-α-dystroglycan mAb - clone IIH6 (Millipore, 05-593), anti-β-DG - clone 7D11 (DSHB)

Comment: See Fig. 1

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Interaction Network Images

Associated Diseases (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of Dag1 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of Dag1

Drosophila — 1 ortholog(s) of Dag1

Human (Homo sapiens) — 1 ortholog(s) of Dag1 Tag

Link to hereSee also

External References

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.