NID2 (Nidogen 2) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000742:EGF-like domain, IPR003886:NIDO domain, IPR001881:EGF-like calcium-binding domain, IPR026823:Complement Clr-like EGF domain, IPR006605:G2 nidogen/fibulin G2F domain, IPR024731:EGF domain, IPR000716:Thyroglobulin type-1 domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of NID2 Tag

Zebrafish (Danio rerio) — 2 ortholog(s) of NID2

Drosophila — 1 ortholog(s) of NID2

Mouse (Mus musculus) — 1 ortholog(s) of NID2

Link to hereProtein Localisation

Localisation Images (1)

C.elegans nid-1 L1 pharynx

Localisation Evidence (4)

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-nid-2 (R&D systems)

Comment: See Fig. 1
Compositional differences between infant and adult human corneal basement membranes. PubMed

Found in: Human (Homo sapiens)

Reagents: Rb anti-NID2/entactin-2 1080 pAb, in house

Comment: See Fig. 5
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-NID2, in house

Comment: See Fig. 1
Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-NID2, in house

Comment: See Fig. 3

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (12)

Gene
COL4A1
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMC1
LAMC3
NID1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/22795 UniProtKB/Q14112

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.