University of Manchester Logo basement membraneBASE bmBASE
ADAM10 AbEnzInt
Entry ID: BMB31072
Ab — Antibody evidence. See the Protein Localisation tab.
Enz — Basement membrane protease. See the BM Substrates tab.
Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species
Human (Homo sapiens)
Gene Symbol
ADAM10
Gene Size (Bases)
160983

Link to hereProtein

Protein Name
Disintegrin and metalloproteinase domain-containing protein 10
Protein Classification
ECM regulator
Protein Molecular Weight (kD)
84
Protein Domains
IPR034025:ADAM10/ADAM17 catalytic domain, IPR001590:Peptidase M12B, ADAM/reprolysin domain, IPR002870:Peptidase M12B, propeptide domain, IPR001762:Disintegrin domain
This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species
Caenorhabditis elegans — 1 ortholog(s) of ADAM10
Zebrafish (Danio rerio) — 2 ortholog(s) of ADAM10
Drosophila — 1 ortholog(s) of ADAM10
Mouse (Mus musculus) — 1 ortholog(s) of ADAM10

Link to hereProtein Localisation

Localisation Images (0)
Localisation Evidence (2)

Link to hereOther Information

Proteomics
BM Substrates (4)
ISLR, MEP1A, MEP1B, MMP17
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
BM Ligands (9)
Gene
AMELX
AMTN
COL17A1
CST3
FBN1
FN1
LAMB1
LAMB2
LAMC1
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
Associated Diseases (1)
Reticulate acropigmentation of Kitamura OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References
Entrez/102 UniProtKB/O14672 WormBase/WBGene00006324#0-9f-10
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.