ADAM10

IPR034025:ADAM10/ADAM17 catalytic domain, IPR001590:Peptidase M12B, ADAM/reprolysin domain, IPR002870:Peptidase M12B, propeptide domain, IPR001762:Disintegrin domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of ADAM10

Zebrafish (Danio rerio) — 2 ortholog(s) of ADAM10

Drosophila — 1 ortholog(s) of ADAM10

Mouse (Mus musculus) — 1 ortholog(s) of ADAM10

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (2)

Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-ADAM-10/KUZBANIAN/MADM polyclonal antibody (Chemicon, AB19026)

Comment: See Fig.1
Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney. PubMed

Found in: Human (Homo sapiens)

Reagents: α-ADAM10 mAb - clone 11G2 (Cell Sciences, CDM442A)

Comment: See Fig. 3 and 6

Link to hereOther Information

Proteomics

BM Substrates (4)

ISLR, MEP1A, MEP1B, MMP17

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (9)

Gene
AMELX
AMTN
COL17A1
CST3
FBN1
FN1
LAMB1
LAMB2
LAMC1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Reticulate acropigmentation of Kitamura OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/102 UniProtKB/O14672 WormBase/WBGene00006324#0-9f-10

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.