ITGA3 (Integrin subunit alpha 3) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

ITGA3 AbTagInt

Entry ID: BMB31176

Ab — Antibody evidence. See the Protein Localisation tab.

Tag — Tagged gene or ortholog (via endogenous labelling). See the Protein Localisation tab.

Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species

Human (Homo sapiens)

Gene Symbol

ITGA3

Gene Size (Bases)

34514

Link to hereProtein

Protein Name

Integrin subunit alpha 3

Protein Classification

Receptor

Protein Molecular Weight (kD)

117

Protein Domains

IPR013649:Integrin alpha-2 domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of ITGA3 Tag

Zebrafish (Danio rerio) — 2 ortholog(s) of ITGA3

Drosophila — 1 ortholog(s) of ITGA3

Mouse (Mus musculus) — 1 ortholog(s) of ITGA3

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - ina-1 L1 pharynx crop

Localisation Evidence (4)

Distribution of integrins during human fetal lung development PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα3 mAb - clone P1B5 (Chemicon, MAB1952Z)

Comment: See Fig. 1
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα3 mAb - clone M-KID2 (Chemicon, MAB1992)

Comment: See Fig. 3
Appearance and distribution of laminin A chain isoforms and integrin alpha 2, alpha 3, alpha 6, beta 1, and beta 4 subunits in the developing human small intestinal mucosa PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα3 mAb - clone P1B5 (Chemicon, MAB1952Z)

Comment: See Fig. 3
Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα3 mAb (Chemicon, AB1920)

Comment: See Fig. 2

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (27)

Gene
AGRN
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL6A1
COL6A2
COL18A1
FN1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
NID1
TGFBI
THBS1
THBS2
VTN

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/3675 UniProtKB/P26006

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.