ITGA6 (Integrin subunit alpha 6) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

ITGA6 AbTagInt

Entry ID: BMB31178

Ab — Antibody evidence. See the Protein Localisation tab.

Tag — Tagged gene or ortholog (via endogenous labelling). See the Protein Localisation tab.

Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species

Human (Homo sapiens)

Gene Symbol

ITGA6

Gene Size (Bases)

79124

Link to hereProtein

Protein Name

Integrin subunit alpha 6

Protein Classification

Receptor

Protein Molecular Weight (kD)

127

Protein Domains

IPR013649:Integrin alpha-2 domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of ITGA6 Tag

Zebrafish (Danio rerio) — 2 ortholog(s) of ITGA6

Drosophila — 1 ortholog(s) of ITGA6

Mouse (Mus musculus) — 1 ortholog(s) of ITGA6

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - ina-1 L1 pharynx crop

Localisation Evidence (4)

Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction PubMed

Found in: Human (Homo sapiens)

Reagents: Rb mAb anti-ITGA6 [EPR18124] (Abcam, ab181551)

Comment: See Fig. 4
Expression of integrins and basement membrane components by wound keratinocytes PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα6 mAb clone GoH3 (Abcam, ab105669)

Comment: See Fig. 7
Distribution of integrins during human fetal lung development PubMed

Found in: Human (Homo sapiens)

Reagents: α-Itgα6 mAb clone GoH3 (Abcam, ab105669)

Comment: See Fig. 1
Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects PubMed

Found in: Human (Homo sapiens)

Reagents: mouse α-Itgα6 mAb (Chemicon)

Comment: See Fig. 2

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (19)

Gene
AGRN
COL4A1
COL4A2
COL6A1
COL17A1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
THBS1
THBS2
VTN

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Epidermolysis Bullosa Junctionalis With Pyloric Atresia OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/3655 UniProtKB/P23229

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.