DAG1 (Dystroglycan 1) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR006644:Dystroglycan-type cadherin-like domain, IPR008465:Dystroglycan, C-terminal domain, IPR030398:DG-type SEA domain, IPR041631:Alpha-dystroglycan N-terminal 2 domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of DAG1 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of DAG1

Drosophila — 1 ortholog(s) of DAG1

Mouse (Mus musculus) — 1 ortholog(s) of DAG1

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - dgn-1 L1 pharynx crop

Localisation Evidence (2)

Podocin and beta dystroglycan expression to study podocyte-podocyte and basement membrane matrix connections in adult protienuric states. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-β-dystroglycan (Vector laboratory, VP-B205)

Comment: See Fig. 1
Dystroglycan expression in human placenta: basement membrane localization and subunit distribution change between the first and third trimester. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-α-dystroglycan mAb - clone IIH6 (Millipore, 05-593)

Comment: See Fig. 1

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (14)

Gene
AGRN
EGFLAM
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (2)

Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 9 OMIM

Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9 OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/1605 UniProtKB/Q14118

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.