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MMP14 EnzInt
Entry ID: BMB31279
Enz — Basement membrane protease. See the BM Substrates tab.
Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species
Human (Homo sapiens)
Gene Symbol
MMP14
Gene Size (Bases)
12468

Link to hereProtein

Protein Name
Matrix Metallopeptidase 14
Protein Classification
ECM regulator
Protein Molecular Weight (kD)
66
Protein Domains
IPR006026:Peptidase, metallopeptidase domain, IPR000585:Hemopexin-like domain, IPR001818:Peptidase M10, metallopeptidase domain, IPR002477:Peptidoglycan binding-like domain, IPR033739:Peptidase M10A, catalytic domain, IPR021805:Peptidase M10A, matrix metallopeptidase, C-terminal domain
This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species
Caenorhabditis elegans — 6 ortholog(s) of MMP14
Zebrafish (Danio rerio) — 2 ortholog(s) of MMP14
Drosophila — 1 ortholog(s) of MMP14
Mouse (Mus musculus) — 1 ortholog(s) of MMP14

Link to hereProtein Localisation

Localisation Images (0)
Localisation Evidence (0)

Link to hereOther Information

Proteomics
Proteomics
BM Substrates (4)
ACAN, COL2A1, FBN1, NID1
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
BM Ligands (19)
Gene
ACAN
DCN
FN1
HSPG2
LAMA3
LAMA5
LAMB1
LAMB3
LAMC1
LAMC2
LUM
MMP2
MMP17
NID1
RECK
SPOCK3
TIMP1
TIMP2
TIMP3
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
Associated Diseases (1)
Winchester Syndrome OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References
Entrez/4323 UniProtKB/P50281
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.