NID1 (Nidogen 1) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000742:EGF-like domain, IPR003886:NIDO domain, IPR001881:EGF-like calcium-binding domain, IPR026823:Complement Clr-like EGF domain, IPR006605:G2 nidogen/fibulin G2F domain, IPR024731:EGF domain, IPR000716:Thyroglobulin type-1 domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of NID1 Tag

Zebrafish (Danio rerio) — 2 ortholog(s) of NID1

Drosophila — 1 ortholog(s) of NID1

Mouse (Mus musculus) — 1 ortholog(s) of NID1

Link to hereProtein Localisation

Localisation Images (1)

C.elegans nid-1 L1 pharynx

Localisation Evidence (2)

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-NID1 (R&D Systems)

Comment: See Fig. 1
Enhanced expression of nidogen 1 around the nest of basal cell carcinoma compared with that around squamous cell carcinoma. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-human nidogen 1/entactin pAb (R&D systems, AF2570)

Comment: See Fig. 1

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (21)

Gene
AGRN
COL4A1
COL4A2
FN1
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMC1
LAMC3
MMP1
MMP7
NID2
SPARC
ITGA3
ITGB1
MMP14

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/4811 UniProtKB/P14543

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.