University of Manchester Logo basement membraneBASE bmBASE
ITGB3 AbTagInt
Entry ID: BMB31255
Ab — Antibody evidence. See the Protein Localisation tab.
Tag — Tagged gene or ortholog (via endogenous labelling). See the Protein Localisation tab.
Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species
Human (Homo sapiens)
Gene Symbol
ITGB3
Gene Size (Bases)
59917

Link to hereProtein

Protein Name
Integrin subunit beta 3
Protein Classification
Receptor
Protein Molecular Weight (kD)
87
Protein Domains
IPR016201:PSI domain, IPR012896:Integrin beta subunit, tail domain, IPR013111:EGF-like domain, extracellular domain, IPR014836:Integrin beta subunit, cytoplasmic domain, IPR033760:Integrin beta N-terminal domain, IPR040622:Integrin beta, epidermal growth factor-like 1 domain, IPR002369:Integrin beta subunit, VWA domain
This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species
Caenorhabditis elegans — 1 ortholog(s) of ITGB3 Tag
Zebrafish (Danio rerio) — 2 ortholog(s) of ITGB3
Drosophila — 1 ortholog(s) of ITGB3
Mouse (Mus musculus) — 1 ortholog(s) of ITGB3

Link to hereProtein Localisation

Localisation Images (1)

C. elegans - pat-3 L1 pharynx crop
Localisation Evidence (2)

Link to hereOther Information

Proteomics
BM Substrates (0)
This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.
BM Ligands (29)
Gene
COL2A1
COL4A1
COL4A2
COL4A3
COL4A4
COL4A5
COL4A6
COL5A1
COL6A1
COL6A2
COL6A3
COL7A1
COL18A1
FBN1
FBN2
FBN3
FN1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMC1
TGFB1
TGFBI
THBS1
TNC
VTN
This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .
Associated Diseases (2)
Bleeding disorder, platelet-type, 16 OMIM
Glanzmann thrombasthenia OMIM
This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References
Entrez/3690 UniProtKB/P05106
If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.