LAMB3 (Laminin Subunit Beta 3) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

LAMB3 AbTagInt

Entry ID: BMB30777

Ab — Antibody evidence. See the Protein Localisation tab.

Tag — Tagged gene or ortholog (via endogenous labelling). See the Protein Localisation tab.

Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species

Human (Homo sapiens)

Gene Symbol

LAMB3

Gene Size (Bases)

37598

Link to hereProtein

Protein Name

Laminin Subunit Beta 3

Protein Classification

ECM glycoprotein

Protein Molecular Weight (kD)

130

Protein Domains

IPR002049:Laminin EGF domain, IPR008211:Laminin, N-terminal domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of LAMB3 Tag

Drosophila — 1 ortholog(s) of LAMB3

Mouse (Mus musculus) — 1 ortholog(s) of LAMB3

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture. PubMed

Found in: Human (Homo sapiens)

Reagents: sc-20775

Comment: See Figure 1
Laminin-511 and -521 enable efficient in vitro expansion of human corneal endothelial cells PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB3 (Thermo Fischer Scientific)

Comment: See Figure 1
Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LN5 ms mAb (Chemicon International)

Comment: See Figure 2
Compositional differences between infant and adult human corneal basement membranes. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB3 ms mAb, clone 6F12

Comment: See Figure 7

Link to hereOther Information

Proteomics

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (29)

Gene
AGRN
COL7A1
COL17A1
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMC1
LAMC2
LAMC3
MMP2
MMP7
CD151
DAG1
ITGA1
ITGA2
ITGA3
ITGA6
ITGA5
ITGAV
ITGB1
RPSA
ITGB4
ITGB5
ITGB6
MMP14

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (3)

Amelogenesis imperfecta, type Ia HPO

226700 HPO

226650 OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/3914 UniProtKB/Q13751

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.