LAMC3 (Laminin Subunit Gamma 3) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

LAMC3 AbTagInt

Entry ID: BMB30789

Ab — Antibody evidence. See the Protein Localisation tab.

Tag — Tagged gene or ortholog (via endogenous labelling). See the Protein Localisation tab.

Int — Basement membrane interaction. See the BM Ligands tab.

Link to hereGene

Species

Human (Homo sapiens)

Gene Symbol

LAMC3

Gene Size (Bases)

85300

Link to hereProtein

Protein Name

Laminin Subunit Gamma 3

Protein Classification

ECM glycoprotein

Protein Molecular Weight (kD)

171

Protein Domains

IPR000742:EGF-like domain, IPR000034:Laminin IV domain, IPR002049:Laminin EGF domain, IPR008211:Laminin, N-terminal domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of LAMC3 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of LAMC3

Drosophila — 1 ortholog(s) of LAMC3

Mouse (Mus musculus) — 1 ortholog(s) of LAMC3

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture. PubMed

Found in: Human (Homo sapiens)

Reagents: C13074

Comment: See Figure 1
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation PubMed

Found in: Human (Homo sapiens)

Reagents: LS-C119566

Comment: See Figure 2
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMC3, in-house

Comment: See Figure 2
Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMC3, in-house

Comment: See Figure 2

Link to hereOther Information

Proteomics

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (23)

Gene
AGRN
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
NID1
NID2
NTN4
DAG1
ITGA1
ITGA2
ITGA3
ITGA6
ITGA5
ITGB1
RPSA

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Cortical malformations, occipital HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/10319 UniProtKB/Q9Y6N6

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.