LAMA5 (Laminin Subunit Alpha 5) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000742:EGF-like domain, IPR001791:Laminin G domain, IPR000034:Laminin IV domain, IPR002049:Laminin EGF domain, IPR008211:Laminin, N-terminal domain, IPR009254:Laminin alpha, domain I domain, IPR010307:Laminin domain II domain, IPR001368:TNFR/NGFR cysteine-rich region domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 2 ortholog(s) of LAMA5 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of LAMA5

Drosophila — 1 ortholog(s) of LAMA5

Mouse (Mus musculus) — 1 ortholog(s) of LAMA5

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (6)

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture. PubMed

Found in: Human (Homo sapiens)

Reagents: Abnova H00003911-M01

Comment: See Figure 1
A novel monoclonal antibody to human laminin α5 chain strongly inhibits integrin-mediated cell adhesion and migration on laminins 511 and 521 PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LNa5 8G9, in-house

Comment: See Figure 2
Nanoscale protein architecture of the kidney glomerular basement membrane. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LNa5 4C7

Comment: See Figures 2 and 5
Autologous transplantation of oral mucosal epithelial cell sheets cultured on an amniotic membrane substrate for intraoral mucosal defects PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LNa5 (Chemicon)

Comment: See Figure 2
Laminin-511 and -521 enable efficient in vitro expansion of human corneal endothelial cells PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LNa5 LEb-L4b domains

Comment: See Figure 1
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LNa5 4C7 (MAB1924, Millipore)

Comment: See Figure 2

Link to hereOther Information

Proteomics

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (36)

Gene
AGRN
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
NID1
NID2
NTN4
USH2A
DAG1
ITGA1
ITGA2
ITGA3
ITGA4
ITGA6
ITGA9
ITGA10
ITGA5
ITGA8
ITGA7
ITGAV
ITGB1
RPSA
ITGB3
ITGB4
ITGB5
ITGB6
SDC1
MMP14

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/3911 UniProtKB/O15230

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.