VCAN (Versican) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000742:EGF-like domain, IPR003599:Immunoglobulin subtype domain, IPR007110:Immunoglobulin-like domain, IPR013106:Immunoglobulin V-set domain, IPR000436:Sushi/SCR/CCP domain, IPR000538:Link domain, IPR001304:C-type lectin-like domain, IPR033987:Aggrecan/versican, C-type lectin-like domain, IPR001881:EGF-like calcium-binding domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Zebrafish (Danio rerio) — 2 ortholog(s) of VCAN

Mouse (Mus musculus) — 1 ortholog(s) of VCAN

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

Altered fibroblast proteoglycan production in COPD PubMed

Found in: Human (Homo sapiens)

Reagents: Rb anti-versican pAb (Santa Cruz Biotechnology)

Comment: See Fig. 1
Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-versican mAb 12C5, Anti-versican mAb 2B1

Comment: See Fig. 2
Podocyte proteoglycan synthesis is involved in the development of nephrotic syndrome PubMed

Found in: Human (Homo sapiens)

Reagents: Rb anti-human VCAN, in house

Comment: See Fig. 3
Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. PubMed

Found in: Human (Homo sapiens)

Reagents: Anti-versican mAb 12C5

Comment: Fig. 4

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (24)

Gene
ADAMTS1
AGRN
AMELX
AMTN
BCAN
BGN
CST3
DCN
FBLN1
FBLN2
FBN1
FMOD
FN1
HSPG2
LAMB1
LAMB2
LAMC1
LUM
SPARCL1
TIMP1
TNC
VWA1
SDC4
SDC1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Wagner Vitreoretinopathy OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/1462 UniProtKB/P13611

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.