AGRN (Agrin) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000082:SEA domain, IPR000742:EGF-like domain, IPR001791:Laminin G domain, IPR001881:EGF-like calcium-binding domain, IPR002049:Laminin EGF domain domain, IPR002350:Kazal domain, IPR003645:Follistatin-like, N-terminal domain, IPR003884:Factor I / membrane attack complex domain, IPR004850:NtA (N-terminal agrin) domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of AGRN Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of AGRN

Mouse (Mus musculus) — 1 ortholog(s) of AGRN

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (5)

Agrin, a novel basement membrane component in human and rat liver, accumulates in cirrhosis and hepatocellular carcinoma. PubMed

Found in: Human (Homo sapiens)

Reagents: ɑ-agrin mAb clone 7E12 (Chemicon)
Characterization of extracellular matrix components in the limbal epithelial stem cell compartment. PubMed

Found in: Human (Homo sapiens)

Reagents: in-house agrin rabbit pAb (PMID: 17927980)
Comparative analysis of the basement membrane composition of the human limbus epithelium and amniotic membrane epithelium. PubMed

Found in: Human (Homo sapiens)

Reagents: in house anti-mouse agrin, LG domain (PMID: 22382594)
Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera PubMed

Found in: Human (Homo sapiens)

Reagents: 6D2 mAb anti-agrin (Developmental Studies Hybridoma Bank)
Nanoscale protein architecture of the kidney glomerular basement membrane. PubMed

Found in: Human (Homo sapiens)

Reagents: in house ɑ-agrinC (clone MI-91) (PMID: 24137544)

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (36)

Gene
COLQ
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
NID1
VCAN
CSPG4
DAG1
GPC1
GPC2
GPC3
GPC4
GPC5
GPC6
ITGA1
ITGA2
ITGA3
ITGA6
ITGA9
ITGA5
ITGA8
ITGA7
ITGAV
ITGB1
MUSK
SDC4
SDC1

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Myasthenic syndrome, congenital, 8 OMIM

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/375790 UniProtKB/O00468

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.