LAMA1 (Laminin Subunit Alpha 1) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

IPR000742:EGF-like domain, IPR001791:Laminin G domain, IPR000034:Laminin IV domain, IPR002049:Laminin EGF domain, IPR008211:Laminin, N-terminal domain, IPR009254:Laminin alpha, domain I domain, IPR009254:Laminin alpha, domain II domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 2 ortholog(s) of LAMA1 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of LAMA1

Drosophila — 1 ortholog(s) of LAMA1

Mouse (Mus musculus) — 1 ortholog(s) of LAMA1

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (3)

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture. PubMed

Found in: Human (Homo sapiens)

Reagents: LS-C25112

Comment: See Figure 1
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation PubMed

Found in: Human (Homo sapiens)

Reagents: LS-C119557

Comment: See Figure S2
Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin PubMed

Found in: Human (Homo sapiens)

Reagents: rb antiserum raised against lamimin a1 HK-175

Comment: See Figure 1

Link to hereOther Information

Proteomics

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. PubMed

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (39)

Gene
AGRN
COL17A1
COL18A1
FBLN2
HSPG2
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB2
LAMB3
LAMC1
LAMC2
LAMC3
NID1
NID2
NTN4
DAG1
GPC1
ITGA1
ITGA2
ITGA3
ITGA4
ITGA6
ITGA9
ITGA10
ITGA5
ITGA8
ITGA7
ITGAV
ITGB1
RPSA
SDC4
ITGB3
ITGB4
ITGB5
ITGB6
ITGB7

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (1)

Poretti-boltshauser Syndrome HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/284217 UniProtKB/P25391

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.