LAMB2 (Laminin Subunit Beta 2) in Human (Homo sapiens) - bmBASE - A resource for basement membrane research

LAMB2 AbTagInt

Entry ID: BMB30774

Ab — Antibody evidence. See the Protein Localisation tab.

Tag — Tagged gene or ortholog (via endogenous labelling). See the Protein Localisation tab.

Int — Basement membrane interaction. See the BM Ligands tab.

Protein Localisation

Other Information

Link to hereGene

Species

Human (Homo sapiens)

Gene Symbol

LAMB2

Gene Size (Bases)

12005

Link to hereProtein

Protein Name

Laminin Subunit Beta 2

Protein Classification

ECM glycoprotein

Protein Molecular Weight (kD)

196

Protein Domains

IPR000742:EGF-like domain, IPR002049:Laminin EGF domain, IPR008211:Laminin, N-terminal domain, IPR013015:Laminin IV type B domain

This list has been manually curated and may not be the most up to date. Further updates may be available on InterPro .

Link to hereOrthology

Orthologs by Species

Caenorhabditis elegans — 1 ortholog(s) of LAMB2 Tag

Zebrafish (Danio rerio) — 1 ortholog(s) of LAMB2

Drosophila — 1 ortholog(s) of LAMB2

Mouse (Mus musculus) — 1 ortholog(s) of LAMB2

Link to hereProtein Localisation

Localisation Images (0)

Localisation Evidence (4)

Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture. PubMed

Found in: Human (Homo sapiens)

Reagents: LS-C88433

Comment: See Figure 1
Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB2, clone 5A (Millipore, 05-206)

Comment: See Figure 2
Nanoscale protein architecture of the kidney glomerular basement membrane. PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB2 rb pAb, LF-domain, in-house

Comment: See Figure 2/S2
Laminin-511 and -521 enable efficient in vitro expansion of human corneal endothelial cells PubMed

Found in: Human (Homo sapiens)

Reagents: anti-LAMB2, in-house

Comment: See Figure 1

Link to hereOther Information

Proteomics

BM Substrates (0)

This list has been manually curated and may not be the most up to date. Further updates may be available on BRENDA.

BM Ligands (38)

Gene
AGRN
AMELX
AMTN
CST3
FBN1
FN1
HSPG2
LAMA1
LAMA2
LAMA3
LAMA4
LAMA5
LAMB1
LAMB3
LAMC1
LAMC2
LAMC3
NID1
NID2
NTN4
SPARCL1
TIMP1
TNC
USH2A
VCAN
VWA1
ADAM10
DAG1
EVA1A
GPC3
ITGA1
ITGA2
ITGA3
ITGA6
ITGA7
ITGB1
RPSA
ITGB4

This list has been manually curated and may not be the most up to date. Further updates may be available on STRING .

Associated Diseases (2)

Nephrotic syndrome, type 5, with or without ocular abnormalitie HPO

Pierson syndrome HPO

This list has been manually curated and may not be the most up to date. Further updates may be available on OMIM and HPO .

Link to hereSee also

External References

Entrez/3913 UniProtKB/P55268

If an 'External Reference' link is broken, please contact the bmbase team directly at - bmbase@manchester.ac.uk.